Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4- hydroxytamoxifen-induced cytotoxicity in ER-positive breast cancer cells
نویسندگان
چکیده
Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4hydroxytamoxifen-induced cytotoxicity in ER-positive breast cancer cells Lei Duan, Natalia Motchoulski, Brian Danzer, Irina Davidovich, Zia Shariat-Madar, Victor V Levenson Department of Radiation Oncology, Rush University Medical Center, 1750 W Harrison Street, Chicago, IL60612. Department of Pharmacology, University of Mississippi, University, MS.
منابع مشابه
A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance.
This study identifies macroautophagy as a key mechanism of cell survival in estrogen receptor-positive (ER+) breast cancer cells undergoing treatment with 4-hydroxytamoxifen (4-OHT). This selective ER modifier is an active metabolite of tamoxifen commonly used for the treatment of breast cancer. Our study provides the following key findings: (a) only 20% to 25% of breast cancer cells treated wi...
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